Preformulation testing is the first step in the rational developmentof dosageforms it can be defined as “an investigation of physical and chemical property of a drug substance alone and. Introduction preformulation can be defined as an investigation of physical and chemical properties of a drug substance alone and when combined with excipients1 the overall objective of.
Recently the high-through put screening for developing the physical and chemical properties of drug substance and excipient most preformulation is start during the lead optimization (lo. The investigation of physical and chemical properties of new drug substances alone or in combination with other excipients also a phase of research and development process preformulation.
Abstract: preformulation is a group of studies that focus on the physicochemical properties of a new drug candidate that could affect the drug performance and the development of a dosage.
Physicochemical factors under preformulation study contents:- i physical characteristics characterize physical & chemical properties of new drug molecule in order to develop safe. It identifies the stable storage conditions for drug products and also investigates any physical or chemical properties of the drug molecule that may affect the stability of a drug product.
Preformulation testing involved investigation of physical and chemical properties of a drug substance alone and when combined with excipients it was the first step in the rational.
Preformulation testing of solid dosage forms 1 preformulation testing of solid dosage forms 2 preformulation testing is the first step in the rational development of dosage forms of a drug.